IN VITRO AND IN VIVO EVALUATION OF FLOATING GASTRORETENTIVE DRUG DELIVERY SYSTEM OF CIMETIDINE USING HARD ALGINATE CAPSULES
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چکیده
منابع مشابه
Design and in vitro Evaluation of Gastroretentive Floating Drug Delivery System of Rosigilitazone Maleate
Rosigilitazone maleate is an anti-diabetic agent is used in the management of Type-II diabetes mellitus. The present investigation concerns the development of the sustained release floating matrix tablets which are designed to exhibit a prolonged gastric residence time and controlling the drug release from the dosage form. This system is useful particularly for achieving controlled plasma level...
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In the present study, Floating Drug Delivery Beads (FDDS) were prepared with sodium alginate/ starch blend as a matrix, sodium hydrogen carbonate as a pore forming agent, methyl cellulose as a binder and barium chloride solution as a hardening agent. In order to prepare the beads with different porosity and morphology the ratio between pore forming agent to polymer blend and ratio of the co...
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A multiple-unit floating drug delivery system based on gas formation technique was developed, in order to prolong the gastric residence time and to increase the overall bioavailability of the dosage form. The floating bead formulations were prepared by dispersing nevirapine together with calcium carbonate in a mixture of sodium alginate and hydroxypropyl methylcellulose solution and then drippi...
متن کاملHollow microspheres for gastroretentive floating- pulsatile drug delivery: preparation and in vitro evaluation.
PURPOSE A multiparticular floating-pulsatile drug delivery system was developed for time and site specific drug release of piroxicam. A blend of floating and pulsatile principles of drug delivery system would have the advantage that a drug can be released in the upper GI tract after a definite time period. METHODS Hollow microspheres were prepared by the emulsion solvent diffusion method usin...
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Atenolol, an antihypertensive drug, has poor bioavailability (40-50%) and has has low elimination half life(6 hr). Atenolol is mainly absorbed in the stomach. The floating tablets of atenolol were prepared to increase the gastric retention, extend the drug release and to improve the bioavailability of the drug. The floating tablets were formulated using HPMC 100 cps, sodium alginate, carbopol 9...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical and Clinical Research
سال: 2018
ISSN: 2455-3891,0974-2441
DOI: 10.22159/ajpcr.2018.v11i6.24731